Hyun‐Woo Rhee

This paper introduces DESTNI, a proximity labeling tool for spatial metabolomics, and demonstrates its application in identifying compartment-specific amino metabolite signatures in live cells.

This paper introduces PF-Map, a probe-free proximity labeling method using water oxidation to generate radicals for spatial protein mapping, revealing a hidden vesicle trafficking subproteome.

The paper identifies endogenous nucleophilic metabolites that neutralize reactive acyl species, reducing protein acylation and extending lifespan in model organisms.

MitoAtlas maps the sub-mitochondrial localization and topology of 861 proteins using SR-PL and AlphaFold, identifying new interactions and unannotated proteins.

The paper identifies the cohibitin complex, including Aim11, as a quality control factor that supports TIM22-mediated insertion of carrier proteins into the mitochondrial inner membrane.

This study introduces HRP-TM, a membrane-localized horseradish peroxidase that uses endogenous H2O2 to label contacting cells, enabling physiological cell-cell interaction analysis without exogenous reagents.

The paper identifies novel TREM2 interactors at the ER-mitochondria interface in human microglia using TurboID proximity labeling, revealing a role for TREM2 in MERC structural plasticity and potential involvement in Alzheimer's disease.

The paper shows IPMK binds to the SWI/SNF complex, regulates BRG1 localization, and affects chromatin accessibility in mouse embryonic stem cells.