A protein phosphatase network controls temporal and spatial dynamics of differentiation commitment in human epidermis
Ajay Mishra, Bénédicte Oulès, Angela Oliveira Pisco, Tony Ly, Kifayathullah Liakath‐Ali, Gernot Walko, Priyalakshmi Viswanathan, Matthieu Tihy, Jagdeesh Nijjher, Sara-Jane Dunn, Angus I. Lamond, Fiona M. Watt
In suspended human keratinocytes, five induced phosphatases dampen ERK to drive differentiation commitment, opposed by DUSP10, in a time-rewired network that renders commitment an unstable switch.
eLife · Oct 18, 2017Peer-reviewedDevelopmental Biology✦ In-depth digest