Matthieu Tihy

Tissular glucocorticoid reactivating enzyme 11beta-HSD1 drives pathogenic myofibroblast differentiation in chronic kidney disease

This study identifies 11beta-HSD1 as a driver of myofibroblast differentiation in CKD, showing its inhibition reduces fibrosis and improves renal function.

The preferential injury of outer renal medulla after ischemia-reperfusion relies on high oxidative metabolism

This study identifies the outer stripe of the outer medulla as the most metabolically active and injured region in the kidney during ischemia-reperfusion injury, showing propofol exacerbates this damage through mitochondrial and fatty acid oxidation impairment.

A protein phosphatase network controls temporal and spatial dynamics of differentiation commitment in human epidermis

In suspended human keratinocytes, five induced phosphatases dampen ERK to drive differentiation commitment, opposed by DUSP10, in a time-rewired network that renders commitment an unstable switch.

Cerebellar Re-Encoding Of Self-Generated Head Movements

The paper shows that caudal cerebellar vermis cells re-encode head movements into a gravity-polarized representation.