Sara-Jane Dunn

This study shows NuRD complex coordinates gene expression during lineage commitment by reducing transcriptional noise, priming genes for activation, and maintaining stable states.

This paper introduces DiscoGen, a neural network-based method for discovering Gene Regulatory Networks that outperforms state-of-the-art causal discovery methods.

Entropy Sorting identifies meaningful cellular heterogeneity in scRNA-seq data, revealing the inner cell mass in human pre-implantation embryos.

This study identifies a common molecular logic governing embryonic stem cell self-renewal and reprogramming through Boolean network analysis and experimental validation.

The paper extends a formal reasoning approach to analyze network motifs and their role in explaining biological behaviors, demonstrating its application to stem cell pluripotency networks.

In suspended human keratinocytes, five induced phosphatases dampen ERK to drive differentiation commitment, opposed by DUSP10, in a time-rewired network that renders commitment an unstable switch.