Tony Ly

Meiotic kinetochore reconstitution identifies chromosome segregation factors

This study reconstitutes vertebrate meiotic kinetochores to identify conserved factors essential for chromosome segregation in mammalian oocytes.

Integrin α11 is enriched in quiescence and promotes cell-cycle re-entry through destabilisation of the CDK inhibitor p27

The paper identifies integrin α11 as a quiescence signature protein that promotes cell-cycle re-entry by destabilizing the CDK inhibitor p27 through YAP-dependent regulation.

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase

The paper develops a chemical-genetic system to inhibit PP2A-B56 phosphatase by blocking SLiM-binding pockets, revealing its role in kinetochore-microtubule attachments.

CD8 T lymphocytes redeploy embryonic cell cycle control mechanisms to facilitate rapid cell proliferation

This study identifies shared cell cycle control mechanisms between CD8 T cells and embryonic stem cells, revealing similarities in cyclin expression and Emi1 function that support rapid proliferation.

Essential role of translation factor eIF5a in cytokine production and cell cycle regulation in primary CD8 T lymphocytes

This study shows that eIF5a modification regulates protein translation in CD8 T cells, affecting cytokine production and cell cycle control during activation.

A flexible microfluidic system for single-cell transcriptome profiling elucidates phased transcriptional regulators of cell cycle

The paper introduces a microfluidic system for single-cell transcriptome profiling and demonstrates its ability to identify cell cycle regulators.

Assembly of a Parts List of the Human Mitotic Cell Cycle Machinery

The paper identifies 701 genes associated with human mitotic phases through transcriptomics analysis, including 205 putative cell cycle genes and 53 uncharacterised ones, with some showing novel centrosomal localization or proliferation inhibition.

A protein phosphatase network controls temporal and spatial dynamics of differentiation commitment in human epidermis

In suspended human keratinocytes, five induced phosphatases dampen ERK to drive differentiation commitment, opposed by DUSP10, in a time-rewired network that renders commitment an unstable switch.