Prolonged Loss of Oxidative Phosphorylation and Mitochondrial Mass Characterize CD66b+ Leukocytes from Patients with Sepsis
Christine Rodhouse, Evan L. Barrios, Leilani Zeumer-Spataro, Leandro Balzano, Ruoxuan Wu, Xuanxuan Yu, Guimei Tian, Jason O. Brant, Marie‐Pierre L. Gauthier, Jing Chen, Miguel Hernandez-Rios, Valerie E. Polcz, Whitman Wiggins, Angel M. Charles, Marvin L. Dirain, , Clayton E. Mathews
This study identifies prolonged reduced oxidative metabolism and mitochondrial mass in CD66b+ leukocytes from sepsis patients, linked to adverse outcomes and gene silencing.
bioRxiv · Dec 18, 2025 · PreprintImmunology