Xuanxuan Yu

This study identifies YAP/TAZ signaling in endothelial cells as a key mediator of abdominal aortic aneurysm formation and shows that pharmacological inhibition reduces AAA progression.

This study identifies prolonged reduced oxidative metabolism and mitochondrial mass in CD66b+ leukocytes from sepsis patients, linked to adverse outcomes and gene silencing.

The paper shows replication stress increases de novo CNVs in Plasmodium falciparum, affecting genes involved in human infection.

This study examines age and sex effects on MDSCs in sepsis using single-cell RNA sequencing, finding differences in expansion, transcriptome, and metabolism.

HapCNV improves CNV detection in low-input haploid sequencing data by using a pseudo-reference to reduce bias and enhance accuracy, especially for short CNVs.

OSCAA improves CNV-disease association analysis by integrating CNV detection and association testing in a single step, enhancing accuracy and power.

This study evaluates methods for estimating correlation coefficients in single-cell sequencing data and finds that filtering zeros and considering drop-out probability improves accuracy.