Clayton E. Mathews

This study identifies transcriptional impairments in mitochondrial and protein homeostasis pathways in islets during type 1 diabetes pathogenesis, independent of T-cell infiltration.

The paper profiles chromatin accessibility in post-sepsis MDSCs, showing divergent epigenetic trajectories between rapid recovery and chronic critical illness, with MHC class II repression in CCI.

This study shows that the IFIH1 E627* variant protects human pancreatic islets from stress-induced dysfunction by reducing immune responses and apoptosis.

This study identifies prolonged reduced oxidative metabolism and mitochondrial mass in CD66b+ leukocytes from sepsis patients, linked to adverse outcomes and gene silencing.

The paper uses single-islet proteomics to analyze pseudo-temporal immune responses and beta-cell dysfunction in stage 1 T1D, identifying key pathways involved in islet dysfunction.

This study identifies a biphasic epigenetic and transcriptional response in macrophages after burn injury, revealing locus-specific chromatin remodeling and immune dysfunction.

This study examines age and sex effects on MDSCs in sepsis using single-cell RNA sequencing, finding differences in expansion, transcriptome, and metabolism.

This study shows that beta cell dysfunction occurs in type 1 diabetes independently of T cell infiltration, using human pancreas tissue slices from recently diagnosed patients.

Laser-microdissected islets of 3 multiple-autoantibody-positive stage 1 type 1 diabetes donors versus matched controls show 202 altered proteins: immune and glycolytic up, translation and ER-stress proteins down.

This study maps epigenetic changes in MDSCs after sepsis, revealing age- and sex-specific chromatin remodeling linked to immune dysfunction.

This paper develops a method to efficiently transduce pancreas tissue slices with CaMPARI2 for analyzing calcium responses, finding size-dependent differences in glucose-induced activity between isolated and slice-islets.

This study identifies chromogranin B (CHGB) as the anion shunt conductance in secretory granules, showing its essential role in granule acidification and regulated secretion.

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

This study shows that blocking CD226 reduces diabetes in NOD mice by enhancing Treg function and reducing effector T cell activity.

This study benchmarks label-free and TMT-MS2 methods for spatial proteome mapping, showing label-free provides deeper coverage and higher dynamic range, while TMT-MS2 offers faster throughput.

This study shows that m6A methylation, regulated by METTL3, controls the innate immune response in β-cells during T1D onset by modulating OAS mRNA stability.

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

The paper presents full-length de novo genome assemblies for 16 inbred mouse strains, identifying strain-specific haplotypes and novel functional loci, including a large unannotated gene with potential developmental roles.