Author

Leilani Zeumer-Spataro

University of Florida Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Angel M. CharlesiD· 3 shared Clayton E. MathewsiD· 3 shared Feifei XiaoiD· 3 shared Guoshuai CaiiD· 3 shared Lyle L. MoldaweriD· 3 shared Michael P. KladdeiD· 3 shared Robert MaileiD· 3 shared Alicia M. MohriD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Angel M. CharlesORCID

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Author profile →

3 papers

Recent·Most cited

Divergent chromatin remodeling in post-sepsis MDSCs underlies MHC class II repression in CCI

Jason Orr Brant, Marie‐Pierre L. Gauthier, Christine E. Rodhouse, Ruoxuan Wu, Miguel Hernández-Ríos, Leilani Zeumer-Spataro, Marvin L. S. Dirain, Ricardo F. Ungaro, Ivanna L. Rocha, Whittman B. Wiggins, Angel M. Charles, Feifei Xiao, Letitia E. Bible, Alicia M. Mohr, Shawn D. Larson, , Michael P. Kladde

The paper profiles chromatin accessibility in post-sepsis MDSCs, showing divergent epigenetic trajectories between rapid recovery and chronic critical illness, with MHC class II repression in CCI.

bioRxiv · Jul 2, 2026 · PreprintImmunology

Prolonged Loss of Oxidative Phosphorylation and Mitochondrial Mass Characterize CD66b+ Leukocytes from Patients with Sepsis

Christine Rodhouse, Evan L. Barrios, Leilani Zeumer-Spataro, Leandro Balzano, Ruoxuan Wu, Xuanxuan Yu, Guimei Tian, Jason O. Brant, Marie‐Pierre L. Gauthier, Jing Chen, Miguel Hernandez-Rios, Valerie E. Polcz, Whitman Wiggins, Angel M. Charles, Marvin L. Dirain, , Clayton E. Mathews

This study identifies prolonged reduced oxidative metabolism and mitochondrial mass in CD66b+ leukocytes from sepsis patients, linked to adverse outcomes and gene silencing.

bioRxiv · Dec 18, 2025 · PreprintImmunology

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis

Christine E. Rodhouse, Dayuan Wang, Hongru Tang, Valerie E. Polcz, Miguel Hernández-Ríos, Xuanxuan Yu, Leandro Balzano‐Nogueira, Jaimar C. Rincon, Angel M. Charles, Seiichiro Fujishima, Quan Vo, Marvin L. S. Dirain, Ricardo F. Ungaro, Dina C. Nacionales, Leilani Zeumer-Spataro, , Philip Alexander Efron

This study examines age and sex effects on MDSCs in sepsis using single-cell RNA sequencing, finding differences in expansion, transcriptome, and metabolism.

bioRxiv · Oct 6, 2025 · PreprintImmunology