ATTRv-V30M Type A amyloid fibrils from the heart and nerves exhibit structural homogeneity.
Binh An Nguyen, Shumaila Afrin, Anna Yakubovska, Virender Pratap Singh, Jaime Vaquer Alicea, Peter Kunach, Preeti Singh, Jaime Vaquer‐Alicea, Yasmin Ahmed, María del Carmen Fernández‐Ramírez, Andrew S. Lemoff, Barbara Kluve‐Beckerman, Lorena Saelices, Lanie Wang, Layla Villalon
This study determines the structure of ATTRv-V30M amyloid fibrils from cardiac and nerve tissues using cryo-EM, finding structural homogeneity across tissues when transthyretin originates from the liver.
Structure · Oct 17, 2024Peer-reviewedBiophysics