Author

Layla Villalon

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biophysics· 3

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein structure prediction· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Binh An NguyeniD· 3 shared Lorena SaelicesiD· 3 shared María del Carmen Fernández‐RamíreziD· 3 shared Andrew S. LemoffiD· 2 shared Barbara Kluve‐Beckerman· 2 shared Bret M. EversiD· 2 shared Christian LópeziD· 2 shared Parker T. BassettiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

Binh An NguyenORCID

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3 papers

Recent·Most cited

Transthyretin amyloid fibrils adopt distinct folds in the brain

Shumaila Afrin, Binh An Nguyen, Parker T. Bassett, María del Carmen Fernández‐Ramírez, Rose Pedretti, Layla Villalon, Candace Kelly, Christian López, Mihir Madabushi, Annie Zhou, Inês Reis, Ricardo Jorge Ferreira Taipa, Bret M. Evers, Lorena Saelices

This study determines cryo-EM structures of brain-derived ATTR fibrils from patients with V30M and V30G variants, revealing distinct folds compared to peripheral tissues.

bioRxiv · May 14, 2026 · PreprintBiophysics

Structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations, revealed by cryo-EM

Binh An Nguyen, María del Carmen Fernández‐Ramírez, Parker T. Bassett, Virender Pratap Singh, Preeti Singh, Maja Pękała, Layla Villalon, Yasmin Ahmed, Andrew S. Lemoff, Bret M. Evers, Christian López, Barbara Kluve‐Beckerman, Lorena Saelices

This study uses cryo-EM to analyze structural variability of apolipoprotein A-I amyloid fibrils across organs and mutations, revealing conformational differences and potential clinical implications.

bioRxiv · Jul 8, 2025 · PreprintBiophysics

ATTRv-V30M Type A amyloid fibrils from the heart and nerves exhibit structural homogeneity.

Binh An Nguyen, Shumaila Afrin, Anna Yakubovska, Virender Pratap Singh, Jaime Vaquer Alicea, Peter Kunach, Preeti Singh, Jaime Vaquer‐Alicea, Yasmin Ahmed, María del Carmen Fernández‐Ramírez, Andrew S. Lemoff, Barbara Kluve‐Beckerman, Lorena Saelices, Lanie Wang, Layla Villalon

This study determines the structure of ATTRv-V30M amyloid fibrils from cardiac and nerve tissues using cryo-EM, finding structural homogeneity across tissues when transthyretin originates from the liver.

Structure · Oct 17, 2024Peer-reviewedBiophysics