Chemical inhibition of pathological reactive astrocytes promotes neural protection
Benjamin L.L. Clayton, James D. Kristell, Kevin Cameron Allan, Molly T. Karl, Eric D. Garrison, Yuka Maeno-Hikichi, Annalise M. Sturno, H. Elizabeth Shick, Robert H. Miller, Paul J. Tesar
This study shows that inhibiting HDAC3 reduces pathological features of reactive astrocytes in vitro and in vivo, promoting neural protection in neurodegenerative diseases.
bioRxiv · Nov 3, 2021 · PreprintNeuroscience