Benjamin L.L. Clayton

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis

The paper uses iPSC-derived glia cultures from MS patients to identify glia-intrinsic disease mechanisms and potential therapeutic targets.

Pervasive environmental chemicals impair oligodendrocyte development

This study identifies two classes of environmental chemicals that impair oligodendrocyte development through distinct mechanisms and links exposure to adverse neurodevelopmental outcomes.

Specialized enteric glial cells coordinate intestinal motility

The paper identifies specialized enteric glial cell subtypes in the mouse duodenum using single nucleus RNA-sequencing and spatial transcriptomics, showing one subtype's role in sensing force via PIEZO2 and its impact on gut motility.

Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

Chemical inhibition of pathological reactive astrocytes promotes neural protection

This study shows that inhibiting HDAC3 reduces pathological features of reactive astrocytes in vitro and in vivo, promoting neural protection in neurodegenerative diseases.

Non-Canonical Targets of HIF1a Drive Cell-Type-Specific Dysfunction

This study identifies non-canonical HIF1a targets that impair oligodendrocyte progenitor cell function and drive disease in chronic hypoxia.