Kevin Cameron Allan

The paper identifies specialized enteric glial cell subtypes in the mouse duodenum using single nucleus RNA-sequencing and spatial transcriptomics, showing one subtype's role in sensing force via PIEZO2 and its impact on gut motility.

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

This study shows that inhibiting HDAC3 reduces pathological features of reactive astrocytes in vitro and in vivo, promoting neural protection in neurodegenerative diseases.

This study identifies non-canonical HIF1a targets that impair oligodendrocyte progenitor cell function and drive disease in chronic hypoxia.

This paper shows that reducing PLP1 expression in a mouse model of PMD improves myelination, motor function, and lifespan, supporting PLP1 suppression as a therapeutic strategy.