Author

James Frick

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander S. BrandisiD· 1 shared Alpha A. LeeiD· 1 shared Andre Schutzer GodoyiD· 1 shared Briana Lynn McGoverniD· 1 shared Charles W.E. TomlinsoniD· 1 shared D. FearoniD· 1 shared David Cousins· 1 shared Ed J. Griffin· 1 shared

Activity by Year

2015-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Alexander S. BrandisORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response

Alpha A. Lee, Isabelle Amick, Jasmin Cara Aschenbrenner, Haim Michael Barr, Jared Benjamin, Alexander S. Brandis, Galit Cohen, Randy Diaz-Tapia, Shirly Duberstein, Jessica Dixon, David Cousins, M. Fairhead, D. Fearon, James Frick, James R. Gayvert, , Max Winokan

The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.

bioRxiv · Aug 19, 2024 · PreprintMicrobiology

Evaluating disease similarity using latent Dirichlet allocation

James Frick, Rajarshi Guha, Tyler Peryea, Noel T. Southall

This paper uses latent Dirichlet allocation to measure disease similarity from text, achieving 0.80 ROC AUC compared to curated Disease Ontology relationships.

bioRxiv · Nov 4, 2015 · PreprintBioinformatics