Author

David Cousins

Primary ORCID profile (0009-0001-0042-6007 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

David CousinsiD1 paper · Department of Primary Industries and Regional Development

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alpha A. LeeiD· 2 shared D. FearoniD· 2 shared F. von DelftiD· 2 shared Haim Michael BarriD· 2 shared James R. GayvertiD· 2 shared Matthew C. RobinsoniD· 2 shared Noa Lahav· 2 shared Peter George MarplesiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Alpha A. LeeORCID

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2 papers

Recent·Most cited

Discovery of orally bioavailable Zika virus NS2B-NS3 protease inhibitors with efficacy in a murine infection model

Nathaniel T. Kenton, Haim Michael Barr, Artem Cherepakha, Lotte Coelmont, Caroline Collard, David Cousins, Geraint H. M. Davies, Oleksii Degtyarenko, Andrew Dirksen, Daniel Elbrecht, D. Fearon, James R. Gayvert, Ed Griffen, Dirk Jochmans, Suzanne J. F. Kaptein, , Alpha A. Lee

The paper identifies orally bioavailable inhibitors of the Zika virus NS2B-NS3 protease that show antiviral activity in vitro and reduce viral RNA load in a murine infection model.

bioRxiv · Jun 19, 2025 · PreprintMicrobiology

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response

Alpha A. Lee, Isabelle Amick, Jasmin Cara Aschenbrenner, Haim Michael Barr, Jared Benjamin, Alexander S. Brandis, Galit Cohen, Randy Diaz-Tapia, Shirly Duberstein, Jessica Dixon, David Cousins, M. Fairhead, D. Fearon, James Frick, James R. Gayvert, , Max Winokan

The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.

bioRxiv · Aug 19, 2024 · PreprintMicrobiology