Author

Randy Diaz-Tapia

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jared BenjaminiD· 3 shared Kris M. WhiteiD· 3 shared Alpha A. LeeiD· 2 shared Briana Lynn McGoverniD· 2 shared Haim Michael BarriD· 2 shared Noa Lahav· 2 shared Rebecca Pearl· 2 shared A. Pashchenko· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiochemistry

Jared BenjaminORCID

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Author profile →

3 papers

Recent·Most cited

Linking biochemical and cellular efficacy of MERS coronavirus main protease inhibitors

Van Ngoc Thuy La, Noa Lahav, Moshe Goldsmith, Mario Rodriguez, Randy Diaz-Tapia, Rebecca Pearl, Briana Lynn McGovern, Jared Benjamin, Haim Michael Barr, Kris M. White, Lulu Kang, John D. Chodera, David D. L. Minh

The paper compares three data analysis methods for MERS-CoV MPro inhibitors, finding that modeling the complete concentration-response curve best predicts cellular efficacy.

ACS Pharmacology & Translational Science · Jun 24, 2026Peer-reviewedBiochemistry

Structure-Activity Relationship Studies Towards Analogues of Pleconaril as Novel Enterovirus-D68 Capsid-Targeting Antivirals

David L. Cousins, Ed Griffen, Jessica Stacey, Alpha A. Lee, Yuliia Filimonova, Anton Hlavin, Yuliia Holota, Roman Khmil, Mykyta V. Kordubailo, Oleksii Kostinov, Dmytro S. Lesyk, Ivan G. Logvinenko, Mariia Lototska, Viacheslav Lysenko, A. Pashchenko, , Kris M. White

The paper investigates structure-activity relationships of pleconaril analogues against EV-D68, identifying compounds with antiviral activity and favorable ADME properties.

bioRxiv · Aug 8, 2025 · PreprintPharmacology & Toxicology

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response

Alpha A. Lee, Isabelle Amick, Jasmin Cara Aschenbrenner, Haim Michael Barr, Jared Benjamin, Alexander S. Brandis, Galit Cohen, Randy Diaz-Tapia, Shirly Duberstein, Jessica Dixon, David Cousins, M. Fairhead, D. Fearon, James Frick, James R. Gayvert, , Max Winokan

The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.

bioRxiv · Aug 19, 2024 · PreprintMicrobiology