Alexander S. Brandis

Disruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Model of Amyloidosis

This study shows that disrupting the brain-spleen axis accelerates disease progression in amyloidosis by impairing monocyte-microglia communication.

Metabolostasis failure thresholds are linked with network topology, metabolite solubility, and translational control

The paper identifies metabolite-specific failure thresholds in yeast linked to network topology, solubility, and translational control, revealing mechanisms of metabolic toxicity and resilience.

Piezo2 in sensory neurons influences systemic and adipose tissue metabolism

This study shows that Piezo2 in sensory neurons regulates brown and beige fat metabolism, preventing systemic hypermetabolism and improving insulin sensitivity.

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response

The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products

This study shows that SARM1 TIR domains produce minor amounts of glycocyclic ADPR molecules in vitro and in bacterial cells, suggesting a potential role in axonal death.

Lowering mutant huntingtin by small molecules relieves Huntington's disease symptoms and progression

This study identifies small molecules that lower mutant huntingtin levels, improving HD symptoms and delaying disease progression in mice.

Accelerated cognitive decline in obese mouse model of Alzheimer's disease is linked to sialic acid-driven immune deregulation

This study shows that obesity accelerates cognitive decline in Alzheimer's mice via sialic acid-driven immune changes.

Deciphering the ‘m6A code’ via quantitative profiling of m6A at single-nucleotide resolution

This paper introduces MASTER-seq, a method to quantitatively profile m6A sites at single-nucleotide resolution, revealing a predictable code that determines m6A stoichiometry and dynamics.