The 16p11.2 microdeletion exacerbates neurodevelopmental alterations induced by early-life microbiome perturbation
Courtney R. McDermott, Zhan Gao, Anya S Mirmajlesi, Christiana Ntim, Katherine D. Kimbark, Divya Thomas, Zain Mughal, Xue‐Song Zhang, Xiaofeng Zhou, Daniel Popov, Alisa Halchenko, Jinchuan Xing, Smita Thakker‐Varia, Janet Alder, James H. Millonig, , Emanuel M. DiCicco-Bloom
This study shows that the 16p11.2 microdeletion worsens neurodevelopmental issues caused by early-life antibiotic exposure, affecting gut microbiota, hippocampal development, and behavior.
bioRxiv · Feb 25, 2025 · PreprintNeuroscience