Jinchuan Xing

This study identifies 19 differentially expressed genes in whole-blood transcriptome profiles of Tourette Disorder patients, achieving high classification accuracy using machine learning models.

The paper introduces a framework to compare and aggregate outputs from multiple Active Module Identification algorithms in genetic interaction networks, finding that no single algorithm performs well across datasets and proposing methods to combine results.

This study shows that the 16p11.2 microdeletion worsens neurodevelopmental issues caused by early-life antibiotic exposure, affecting gut microbiota, hippocampal development, and behavior.

The study identifies genetic determinants of reproductive aging linked to egg aneuploidy by analyzing maternal exomes and shows kinesin gene variants contribute to aneuploidy and accelerated aging.

The paper uses ulc-WGS data from PGT-A to identify a genetic locus associated with maternal meiotic aneuploidy risk and validates its function in mouse oocytes.

The paper identifies 65 novel meiotic and fertility genes in Drosophila melanogaster through RNAi screening, showing their role in infertility and chromosomal nondisjunction.

This study identifies shared genetic risk factors for ASD and ADHD using whole genome sequencing data from families with co-occurring disorders.

The paper identifies polymorphic mobile element insertions (pMEIs) as contributors to gene expression and alternative splicing variations across 48 human tissues using GTEx data.

This study sequenced and assembled the genome of the Asian honey bee Apis dorsata, identifying unique genes and transposable elements associated with its defensive behavior.

The paper estimates human retrotransposition rates for L1, Alu, and SVA elements using WGS data from 33 three-generation pedigrees, finding rates and parent-of-origin effects.

This study shows CDX2 has different chromatin-binding profiles in embryonic and adult intestines, leading to distinct gene activation patterns and developmental outcomes.

The paper defines functional equivalence standards for genome sequencing pipelines to enable harmonized variant calling across diverse datasets with minimal batch effects.

This study investigates the role of Piwil1 in mouse neocorticogenesis, finding it essential for cell cycle, neuron migration, and dendritogenesis, with effects independent of piRNA expression.