α5-GABA-A Receptor Positive Allosteric Modulation prevents neuronal atrophy and cognitive decline independently of p-Tau accumulation in the PS19 mouse model
Ravinder Naik Dharavath, Ashley M. Bernardo, Cassandra Marceau-Linhares, Michael D Marcotte, Carla Elena Mezo‐González, Kayla D Wong, Celeste Pina‐Leblanc, Adrien Bouchet, Dishary Sharmin, Kamal Prasad Pandey, James M. Cook, Thomas D. Prévot, Etienne L. Sibille
The paper shows that 5-GABA-A receptor positive allosteric modulation improves neuronal morphology and cognitive function in a mouse model of tauopathy without affecting p-Tau levels.
bioRxiv · Sep 7, 2024 · PreprintNeuroscience