NKCC1 as a signaling hub regulating KCC2 stability, chloride homeostasis, and seizure susceptibility
Erwan Pol, Célia Delhaye, Silvia Cases‐Cunillera, Marion Russeau, Simon Blachier, Adrien Bouchet, Christophe Piesse, Johan Pallud, Gilles Huberfeld, Nicolas Pietrancosta, Sabine Lévi
The paper identifies NKCC1 as a signaling hub that regulates KCC2 stability and chloride homeostasis, showing that peptides targeting NKCC1 can reduce seizure frequency in epilepsy.
bioRxiv · Dec 9, 2025 · PreprintNeuroscience