Cellular tolerance at the μ-opioid receptor is phosphorylation dependent
Seksiri Arttamangkul, Daniel A Heinz, James R. Bunzow, Xianqiang Song, John T. Williams
This study shows that phosphorylation of the μ-opioid receptor (MOR) is essential for desensitization, internalization, and long-term tolerance to morphine in locus coeruleus neurons.
eLife · Mar 28, 2018Peer-reviewedNeuroscience