NeuroscienceeLifePeer-reviewed
Cellular tolerance at the μ-opioid receptor is phosphorylation dependent
Seksiri Arttamangkul, Daniel A Heinz, James R. Bunzow…·John T. Williams
This study shows that phosphorylation of the μ-opioid receptor (MOR) is essential for desensitization, internalization, and long-term tolerance to morphine in locus coeruleus neurons.
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