Interaction of an alpha-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson's disease
Francesca Garretti, Connor Monahan, Nicholas Sloan, Jamie Bergen, Sanjid Shahriar, Seon Woo Kim, Alessandro Sette, Tyler Cutforth, Ellen Kanter, Dritan Agalliu, David L. Sulzer
This study shows that immunizing HLA-DRB1*15:01 mice with the alpha-synuclein epitope -syn32-46 causes intestinal inflammation, neuron loss, and constipation, mimicking prodromal Parkinson's disease features.
Neuron · Aug 18, 2023Peer-reviewedNeuroscience