NeuroscienceNeuronPeer-reviewed
Interaction of an alpha-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson's disease
Francesca Garretti, Connor Monahan, Nicholas Sloan…·David L. Sulzer
This study shows that immunizing HLA-DRB1*15:01 mice with the alpha-synuclein epitope -syn32-46 causes intestinal inflammation, neuron loss, and constipation, mimicking prodromal Parkinson's disease features.
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