Dritan Agalliu

Modulating the Novel miR-23b-Wnt/β-catenin Axis Strengthens Endothelial Barrier Properties

This study identifies miR-23b as a negative regulator of BBB integrity and shows that anti-miR-23b enhances barrier function through multiple signaling pathways and improves outcomes in a stroke model.

High prevalence of CNS-directed autoantibodies in patients with schizophrenia

This study identifies a high prevalence of CNS-directed autoantibodies in schizophrenia patients, linking them to disease severity, treatment resistance, and potential therapeutic targets.

Safe focused ultrasound-mediated blood-brain barrier opening is driven primarily by transient reorganization of tight junctions

This study investigates how focused ultrasound opens the blood-brain barrier at low and high pressures, finding that low pressures cause transient tight junction reorganization while high pressures lead to irreversible damage.

Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in post-streptococcal encephalitis

This study identifies IL-17A-IL-17RA signaling in microglia as a critical driver of BBB dysfunction after GAS infections using single-cell RNA sequencing and spatial transcriptomics.

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury

This study identifies endothelial type I interferon signaling as a regulator of vascular normalization after ischemic brain injury, showing it reduces BBB disruption and promotes junctional stability.

Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling

This study shows that glutamatergic neuronal activity influences retinal angiogenesis and blood-retinal barrier maturation through Norrin/β-catenin signaling in mice.

Generation of hiPSC-derived brain microvascular endothelial cells using a combination of directed differentiation and transcriptional reprogramming strategies

This paper generates and characterizes reprogrammed brain microvascular endothelial cells from hiPSCs using transcription factors FOXF2 and ZIC3, showing improved BBB properties and integration with neural cells in a 3D system.

Interaction of an alpha-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson's disease

This study shows that immunizing HLA-DRB1*15:01 mice with the alpha-synuclein epitope -syn32-46 causes intestinal inflammation, neuron loss, and constipation, mimicking prodromal Parkinson's disease features.

Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis

The paper investigates how Th17 cytokines influence microglial and blood-brain barrier responses during post-infectious encephalitis using single-cell RNA sequencing and spatial transcriptomics.

Single-cell RNA sequencing implicates venous endothelial cells as a source of VEGF-A-mediated neo-angiogenesis in neuroinflammation

Mural norrin/β-catenin signaling regulates Lama2 expression to promote neurovascular unit assembly

This study shows that Norrin/β-catenin signaling in mural cells increases Lama2 expression, which promotes neurovascular unit assembly and barrier maturation.

Vascular-Derived SPARC and SerpinE1 Regulate Interneuron Tangential Migration and Accelerate Functional Maturation of Human Stem Cell-Derived Interneurons

Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation

This paper shows that systemic prophylactic CpG-C treatment reduces brain metastasis in mice by activating microglia to kill and phagocytize tumor cells.