Author

Tyler Cutforth

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1

Frequent Co-Authors

Dritan AgalliuiD· 4 shared Bogoljub ĆirićiD· 2 shared Charlotte R. WayneiD· 2 shared Dorothy P. SchaferiD· 2 shared Luca BremneriD· 2 shared Nicole Ampatey· 2 shared Panos Arvanitis· 2 shared Sanjid ShahriariD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersNeuroscience

Dritan AgalliuORCID

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Author profile →

4 papers

Recent·Most cited

Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in post-streptococcal encephalitis

Charlotte R. Wayne, Uğur Akcan, Travis E. Faust, Violeta Durán-Laforet, Danny Jamoul, Luca Bremner, Nicole Ampatey, Busra Turan Akcan, Sarah J. Ho, Bogoljub Ćirić, Shannon L. Delaney, Wendy S. Vargas, Susan E. Swedo, Vilas Menon, Dorothy P. Schafer, , Dritan Agalliu

This study identifies IL-17A-IL-17RA signaling in microglia as a critical driver of BBB dysfunction after GAS infections using single-cell RNA sequencing and spatial transcriptomics.

bioRxiv · Feb 7, 2026 · PreprintNeuroscience

Interaction of an alpha-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson's disease

Francesca Garretti, Connor Monahan, Nicholas Sloan, Jamie Bergen, Sanjid Shahriar, Seon Woo Kim, Alessandro Sette, Tyler Cutforth, Ellen Kanter, Dritan Agalliu, David L. Sulzer

This study shows that immunizing HLA-DRB1*15:01 mice with the alpha-synuclein epitope -syn32-46 causes intestinal inflammation, neuron loss, and constipation, mimicking prodromal Parkinson's disease features.

Neuron · Aug 18, 2023Peer-reviewedNeuroscience

Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis

Charlotte R. Wayne, Luca Bremner, Travis E. Faust, Violeta Durán‐Laforet, Nicole Ampatey, Sarah J. Ho, Philip A. Feinberg, Panos Arvanitis, Bogoljub Ćirić, Chun‐Sheng Ruan, Wassim Elyaman, Shannon L. Delaney, Wendy S. Vargas, Susan E. Swedo, Vilas Menon, , Dritan Agalliu

The paper investigates how Th17 cytokines influence microglial and blood-brain barrier responses during post-infectious encephalitis using single-cell RNA sequencing and spatial transcriptomics.

bioRxiv · Mar 10, 2023 · PreprintNeuroscience

Mural norrin/β-catenin signaling regulates Lama2 expression to promote neurovascular unit assembly

Saptarshi Biswas, Sanjid Shahriar, Nicholas Giangreco, Panos Arvanitis, Markus Winkler, Nicholas P. Tatonetti, William J. Brunken, Tyler Cutforth, Dritan Agalliu

This study shows that Norrin/β-catenin signaling in mural cells increases Lama2 expression, which promotes neurovascular unit assembly and barrier maturation.

bioRxiv · Feb 18, 2022 · PreprintDevelopmental Biology