Selection of potent biologic antagonists of the cannabinoid GPCR CB2R from a constrained peptide library
Robert S. Leddy, Ajay Pal, jamie plant, Cian McBrien, Y Li, Hannah M Phelan, Sara Snogerup Linse, Calen Steiner, Colm Collins, David J O’Connell
The paper identifies potent CB2R antagonists from a peptide library that inhibit gut homing in a mouse model of Crohn's disease.
bioRxiv · Jul 3, 2026 · PreprintImmunology