Hannah M Phelan

This paper shows that CB2R activation in T cells increases glucose uptake and shifts metabolism toward oxidative phosphorylation and the pentose phosphate pathway, with effects dependent on the receptor.

The paper identifies potent CB2R antagonists from a peptide library that inhibit gut homing in a mouse model of Crohn's disease.

This study shows that CB2R signaling promotes T cell gut-homing in a preclinical Crohn's model by enhancing integrin 4β7 expression and transmigration across gut endothelial barriers.