Author

David J O’Connell

University College DublinORCID 0000-0002-6461-7750Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Hannah M Phelan· 2 shared Robert S. LeddyiD· 2 shared Ajay PaliD· 1 shared Calen Steiner· 1 shared Carol M. AherneiD· 1 shared Cian McBrieniD· 1 shared Claire ConnollyiD· 1 shared Colm B. CollinsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Hannah M Phelan

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cannabinoid CB2 receptor activation drives glucose uptake, shifting T cell metabolism.

Robert S. Leddy, Hannah M Phelan, Claire Connolly, Fabian Wehrmann, D Winter, Lorraine Brennan, David J O’Connell, Carol M. Aherne, Colm B. Collins

This paper shows that CB2R activation in T cells increases glucose uptake and shifts metabolism toward oxidative phosphorylation and the pentose phosphate pathway, with effects dependent on the receptor.

bioRxiv · Jul 10, 2026 · PreprintImmunology

Selection of potent biologic antagonists of the cannabinoid GPCR CB2R from a constrained peptide library

Robert S. Leddy, Ajay Pal, jamie plant, Cian McBrien, Y Li, Hannah M Phelan, Sara Snogerup Linse, Calen Steiner, Colm Collins, David J O’Connell

The paper identifies potent CB2R antagonists from a peptide library that inhibit gut homing in a mouse model of Crohn's disease.

bioRxiv · Jul 3, 2026 · PreprintImmunology