High-Sensitivity Top-Down Proteomics Reveals Enhanced Maturation of Micropatterned Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Mallory C. Wilson, Mitchell B. Josvai, Janay K. Walters, Jodi Lawson, Kalina J. Rossler, Zhan Gao, Yanlong Zhu, Timothy J. Kamp, Wendy C. Crone, Lee L. Eckhardt, Ying Ge
The paper develops a high-sensitivity protein extraction method for micropatterned hiPSC-CMs and shows they exhibit more mature molecular signatures compared to traditional cultures.
Journal of Proteome Research · Aug 26, 2025Peer-reviewedMolecular Biology