Yanlong Zhu

This study identifies molecular pathways and regulatory programs associated with hPSC-CM maturation through multi-omic profiling during long-term culture.

This study uses proteomics to show that aging, sex, and region affect lung ECM remodeling, with age being the main factor and females showing more pronounced changes.

This paper presents a multi-omics platform for simultaneous lipid, metabolite, and protein analysis of sEVs using sequential extraction and mass spectrometry, achieving deep and reproducible characterization with 10 million sEVs.

The paper develops a high-sensitivity protein extraction method for micropatterned hiPSC-CMs and shows they exhibit more mature molecular signatures compared to traditional cultures.

This paper presents a comprehensive metabolomic analysis of human heart tissue using parallel extraction methods and high-resolution mass spectrometry to identify 2276 metabolites across a wide range of polarities.

This study develops a method to analyze the human lung ECM proteome using photocleavable surfactant and diaPASEF, identifying nearly 400 unique matrisome proteins.

This study compares the functional and molecular properties of engineered cardiac tissue constructs made from hiPSC-CMs purified by lactate or MACS methods, finding no significant differences.

The paper develops a multi-omics method to analyze metabolome and proteome of hPSC-CMs, identifying overrepresented pathways in protein synthesis and cardiac function.