Ying Ge

This study identifies molecular pathways and regulatory programs associated with hPSC-CM maturation through multi-omic profiling during long-term culture.

The paper uses integrated mass spectrometry to show AMPK phosphorylation occurs through hierarchical proteoform cascades with specific kinetic priorities and regulatory control.

This study uses proteomics to show that aging, sex, and region affect lung ECM remodeling, with age being the main factor and females showing more pronounced changes.

This paper presents a multi-omics platform for simultaneous lipid, metabolite, and protein analysis of sEVs using sequential extraction and mass spectrometry, achieving deep and reproducible characterization with 10 million sEVs.

This study uses quantitative proteomics to identify ECM protein alterations in end-stage ICM, revealing key upregulated components and pathways involved in adverse remodeling.

The paper develops a high-sensitivity protein extraction method for micropatterned hiPSC-CMs and shows they exhibit more mature molecular signatures compared to traditional cultures.

This study uses integrated top-down mass spectrometry to reveal structural heterogeneity in AMPK proteoform-ligand complexes, uncovering new insights into kinase regulation.

This study designs a stable heterotrimeric protein complex using rational design and native mass spectrometry, validated by X-ray crystallography.

The paper develops a method for high-throughput structural analysis of endogenous protein complexes using native top-down proteomics.

The paper identifies ssTnI overexpression as enhancing cardiomyocyte proliferation and regenerative capacity post-MI through metabolic shifts.

The paper identifies and quantifies S-glutathionylation in ventricular myosin light chain 1 across human, swine, and mouse cardiac tissues using top-down proteomics.

This paper presents a comprehensive metabolomic analysis of human heart tissue using parallel extraction methods and high-resolution mass spectrometry to identify 2276 metabolites across a wide range of polarities.

This study develops a method to analyze the human lung ECM proteome using photocleavable surfactant and diaPASEF, identifying nearly 400 unique matrisome proteins.

This study shows that mTORC1 inhibition accelerates the metabolic switch from glycolysis to fatty acid oxidation in neonatal heart injury, impairing regeneration.

The paper uses top-down proteomics to analyze MLC-1 and -2 isoform expression in human heart chambers, revealing chamber-specific patterns and a novel PTM.

MASH Native provides a unified software solution for processing native top-down proteomics data, offering database searching and analysis tools in a user-friendly interface.

This study compares the functional and molecular properties of engineered cardiac tissue constructs made from hiPSC-CMs purified by lactate or MACS methods, finding no significant differences.

This study shows BRD4 regulates alternative splicing of immune-related genes in airway epithelial cells during viral infection, affecting innate inflammation and protein processing.

The paper develops a multi-omics method to analyze metabolome and proteome of hPSC-CMs, identifying overrepresented pathways in protein synthesis and cardiac function.

The paper introduces an ultrafast proteomics method using Azo and timsTOF Pro to enable high-throughput, reproducible protein identification and quantification from small amounts of human heart tissue.