Effect of Genetic and Dietary Perturbation of Glycine Metabolism on Atherosclerosis in Humans and Mice
Subarna Biswas, James R. Hilser, Nicholas C. Woodward, Zeneng Wang, Janet Gukasyan, Ina Nemet, William S. Schwartzman, Pin Huang, Yi Ying Han, Zachary Fouladian, Sarada Charugundla, Neal J. Spencer, Calvin Pan, W.H. Wilson Tang, Aldons Jake Lusis, , Hooman Allayee
This study investigates the causal relationship between circulating glycine levels and atherosclerosis using genetic analyses in humans and dietary experiments in mice, finding no strong causal evidence despite observational associations.
medRxiv · Dec 8, 2023 · PreprintGenetic & Genomic Medicine