Calvin Pan

The p53-p21-Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLD.

Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits

The paper uses sex-stratified analyses to explore genetic architecture of complex traits in mice and humans, finding high concordance in allelic effect directions and suggesting new methods for identifying biologically significant associations.

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

Systems genetics approach uncovers associations between host amylase locus, gut microbiome and metabolic traits in hyperlipidemic mice

This study identifies genetic loci linking host amylase genes to gut microbiome composition and metabolic traits in hyperlipidemic mice.

Effect of Genetic and Dietary Perturbation of Glycine Metabolism on Atherosclerosis in Humans and Mice

This study investigates the causal relationship between circulating glycine levels and atherosclerosis using genetic analyses in humans and dietary experiments in mice, finding no strong causal evidence despite observational associations.

Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse

This study identifies shared and distinct genetic pathways between human and mouse in coronary artery disease using multi-omics data and GWAS, showing over 75% shared pathways.

The Genetic Architecture of Dietary Iron Overload and Associated Pathology in Mice

This study investigates the genetic basis of dietary iron overload and associated pathologies in mice using the Hybrid Mouse Diversity Panel, identifying genetic loci and pathways involved.

Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy

The paper identifies three genetic loci influencing mitochondrial proteins and heart hypertrophy in mice using proteomics and association mapping.

Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.

This study shows that fructose metabolism via KHK-C increases ER stress and modulates the hepatic transcriptome, contributing to NAFLD progression in both genetic and diet-induced models.

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes

This study uses transcriptome-wide association analysis to identify 114 genes associated with coronary artery disease, including 18 novel genes, and shows they are enriched in lipid metabolism pathways.

Genetic control of fetal placental genomics contributes to development of health and disease

The paper identifies placental gene-trait associations across the life course using multi-omics data, finding genetic effects on early-life traits but not later ones.

Large-scale Genetic Analysis Identifies 66 Novel Loci for Asthma

This study identifies 66 novel asthma susceptibility loci through GWAS and finds gene-sex interactions and immune-related candidate genes, suggesting CD52 as a potential therapeutic target.

Genetic control of the HDL proteome

The paper identifies genetic regulation of HDL proteome variation across mouse strains, revealing coordinated protein regulation and functional diversity in HDL subspecies.

Epigenome-wide association in adipose tissue from the METSIM cohort

The paper identifies DNA methylation associations with metabolic syndrome traits in adipose tissue and develops a biomarker for type II diabetes risk.