Author

Hooman Allayee

University of California, Los AngelesORCID 0000-0002-2384-5239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genetic & Genomic Medicine· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Aldons Jake LusisiD· 3 shared Jaana HartialaiD· 3 shared Brian J. BennettiD· 2 shared Calvin PaniD· 2 shared Diana M. ShihiD· 2 shared James R. HilseriD· 2 shared Janet Gukasyan· 2 shared Nicholas C. Woodward· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersGenetics

Aldons Jake LusisORCID

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Author profile →

5 papers

Recent·Most cited

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Eric R. McGregor, James R. Hilser, Ruben Aquino-Martinez, Sandra Harding, Joseph Lawrence Harpt, Katharina R. Beck, Hailey Bussan, Jessamine F. Kuehn, Yuetiva Deming, Rachel Studer, Sterling C. Johnson, Sanjay Asthana, , Federico E. Rey

This study identifies imidazole propionate as a gut bacterial metabolite linked to Alzheimer's disease pathology through human and mouse experiments.

Nature Communications · Jun 26, 2026Peer-reviewedPathology

Primary-Level Meta-Analysis of Diversity Outbred Mice Identifies a Fasting Plasma Trimethylamine N-Oxide (TMAO) Locus Modified by Sex and Diet

Kristen J. Sutton, Levi W. Evans, Erik Gertz, Dawson Budke, M. Nazmul Huda, Phoebe Yam, Myungsuk Kim, Jennifer M. Rutkowsky, Diana M. Shih, Jaana Hartiala, Daniel Pomp, Aldons Jake Lusis, Hooman Allayee, Brian J. Bennett

The paper identifies a TMAO locus on mouse chromosome 12 modified by sex and diet through a meta-analysis of 1,482 Diversity Outbred mice.

bioRxiv · Jun 24, 2026 · PreprintGenetics

Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerability

Jenny Yeuk‐Ki Cheng, Michael Cheng, Satyesh K. Sinha, Ingrid Cely, Sharda Charugundla, Maggie Han, Guanglin Zhang, Zhiqiang Zhou, Sasha Gladkikh, In Sook Ahn, Graciel Diamante, Yu-Chen Wang, Zeneng Wang, Brian J. Bennett, Hua “Linda” Cai, , Diana M. Shih

This study shows TMAO affects cell type-specific pathways in mouse aorta, promoting atherosclerotic plaque instability by increasing apoptosis and reducing ECM formation.

Arteriosclerosis Thrombosis and Vascular Biology · Aug 14, 2025Peer-reviewedPhysiology

Effect of Genetic and Dietary Perturbation of Glycine Metabolism on Atherosclerosis in Humans and Mice

Subarna Biswas, James R. Hilser, Nicholas C. Woodward, Zeneng Wang, Janet Gukasyan, Ina Nemet, William S. Schwartzman, Pin Huang, Yi Ying Han, Zachary Fouladian, Sarada Charugundla, Neal J. Spencer, Calvin Pan, W.H. Wilson Tang, Aldons Jake Lusis, , Hooman Allayee

This study investigates the causal relationship between circulating glycine levels and atherosclerosis using genetic analyses in humans and dietary experiments in mice, finding no strong causal evidence despite observational associations.

medRxiv · Dec 8, 2023 · PreprintGenetic & Genomic Medicine

Large-scale Genetic Analysis Identifies 66 Novel Loci for Asthma

Yi Ying Han, Qiong Jia, Pedram Shafiei-Jahani, Benjamin P. Hurrell, Calvin Pan, Pin Huang, Janet Gukasyan, Nicholas C. Woodward, Eleazar Eskin, Frank D. Gilliland, Omid Akbari, Jaana Hartiala, Hooman Allayee

This study identifies 66 novel asthma susceptibility loci through GWAS and finds gene-sex interactions and immune-related candidate genes, suggesting CD52 as a potential therapeutic target.

bioRxiv · Aug 29, 2019 · PreprintGenetics