W.H. Wilson Tang

AT1R-Selective Negative Allosteric Modulator Targeting the Epitope for Pathogenic Autoantibody Activation

This paper develops TP1, an AT1R-selective negative allosteric modulator that blocks autoantibody binding and preserves orthosteric functions, showing therapeutic potential for autoimmune conditions.

Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement

The paper examines gut microbiome changes in chronic systolic heart failure patients, linking microbiome alterations to disease severity and clinical improvement.

Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction

This study identifies dysregulated nitrosylation dynamics in HFpEF patients and ZSF1 obese rats, showing elevated nitrosative stress markers and impaired trans- and de-nitrosylase activity.

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism

This study shows H2S deficiency in HFpEF patients and models, and that H2S supplementation or combination with GLP-1/glucagon agonists improves HFpEF outcomes.

Implementing Precision Medicine for Dilated Cardiomyopathy: Insights from The DCM Consortium

This study identifies barriers and needs for genetic evaluation in dilated cardiomyopathy through a survey and discussion with cardiologists, highlighting the need for improved reimbursement, education, and infrastructure.

Effect of Genetic and Dietary Perturbation of Glycine Metabolism on Atherosclerosis in Humans and Mice

This study investigates the causal relationship between circulating glycine levels and atherosclerosis using genetic analyses in humans and dietary experiments in mice, finding no strong causal evidence despite observational associations.

Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure

The paper identifies PPP1R3A as a central cardioprotective factor in pressure overload heart failure by analyzing gene network rewiring in human hearts.