Disassembly of the Escherichia coli AcrABZ-TolC efflux pump by ligand-mediated disruption of TolC-AcrA interfacial contacts
Tania Szal, Emmanouela Petsolari, Janis Veliks, Cristina D. Cruz, Laura Paunina, Marina Madre, Fatima-Zahra Rachad, Philipp Lewe, Susanne Witt, Päivi Tammela, Aigars Jirgensons, Ben F. Luisi, Björn Windshügel
The paper identifies a compound that disrupts the TolC-AcrA interface of the E. coli efflux pump, leading to pump disassembly and reduced antibiotic resistance.
bioRxiv · Feb 18, 2025 · PreprintMicrobiology