Colon-delivered multivitamin supplementation enhances working memory-related fMRI responses in older adults: a randomized, placebo-controlled trial
Lianne B. Remie, Mark R. van Loenen, Mechteld M. Grootte Bromhaar, Noortje M. P. Overwater, Janne van Overbeek, Andrea Anesi, Urška Vrhovšek, Ateequr Rehman, Robert E. Steinert, Jurriaan J. Mes, Guido J. E. J. Hooiveld, Wilma T. Steegenga, Joukje M. Oosterman, Mara P. H. van Trijp, Esther Aarts
This study investigates the effect of colon-delivered multivitamins on neurocognitive outcomes in older adults, finding increased fMRI responses in specific brain regions but no significant changes in SCFA levels or WM performance.
bioRxiv · Mar 12, 2026 · PreprintNeuroscience