Explainable AI identifies H3K18ac as a new marker of active enhancers
Khizra Maqsood, Duarte Polvora Brandao, Jareth Wolfe, Bhavana Kayyar, Catalin G Clinciu, Roxana Andreea Bosnea, Olivia A. Grant, Fanny Boulet, Christopher G. Bell, Gabriella Ficz, Madapura M. Pradeepa, Hani Hagras, Nicolae Radu Zabet
The paper develops AI models to predict enhancers in human and mouse cell lines, identifying H3K18ac as a new enhancer marker and annotating enhancers using a combination of epigenetic marks.
bioRxiv · Jun 11, 2026 · PreprintGenomics