Madapura M. Pradeepa

Acute BRD4 degradation and BD2 mutations de-repress bivalent developmental and neuronal genes in human stem cells and organoids, consistent with BRD4 recruitment by H3K14ac/H3K23ac and interaction with PRC1.6.

The paper develops AI models to predict enhancers in human and mouse cell lines, identifying H3K18ac as a new enhancer marker and annotating enhancers using a combination of epigenetic marks.

The paper identifies non-canonical enhancers in human pluripotent stem cells that lack typical enhancer features but regulate gene expression and cell fate.

This study shows MLL2 stabilizes 3D chromatin loops during pluripotent cell differentiation without requiring its enzymatic activity.

This study identifies a transposable element (TE) signature in maternal cell-free RNA that predicts preeclampsia with high accuracy.

This study identifies patient-specific and common nucleosome repositioning patterns in breast cancer tissues and links them to cancer pathways and liquid biopsy applications.

This study shows PSIP1 reduces R-loops at transcription sites, preventing DNA damage and maintaining genome integrity in human and mouse cells.

The paper identifies non-coding mutations in enhancer clusters associated with pancreatic ductal adenocarcinoma and validates their functional impact using computational and experimental methods.

The paper shows H4K16ac activates LINE1 and LTR transcription, contributing to cis-regulatory function by maintaining active chromatin at TEs.

This study identifies regulatory de novo mutations in fetal brain-specific enhancers as a significant contributor to intellectual disability.

This study shows that genetic variation in rDNA affects epigenetic states and rRNA expression in mice and humans, with species-specific patterns observed.

The paper identifies de novo variants in fetal brain enhancers linked to intellectual disability by analyzing genomic data from affected individuals and their parents.