Surface GluA1 and glutamate transmission are increased in VPS35 D620N neurons and altered by LRRK2 kinase inhibition
Chelsie Kadgien, Anusha Kamesh, Jaskaran Khinda, Li Ping Cao, Jesse Fox, Matthew James Farrer, Austen J. Milnerwood
This study investigates the effects of the VPS35 D620N mutation on neuronal function, finding increased GluA1 surface expression and altered glutamate transmission, with LRRK2 inhibition affecting GluA1 levels.
Molecular Brain · Sep 16, 2021Peer-reviewedNeuroscience