Author

Chelsie Kadgien

Montreal Neurological Institute and HospitalORCID 0000-0003-0238-6421Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:electronic health records· 1

Frequent Co-Authors

Anusha KameshiD· 2 shared Austen J. MilnerwoodiD· 2 shared Agostinho SantosiD· 1 shared Andrea PietrantonioiD· 1 shared Anouar KhayachiiD· 1 shared Emily P. HurleyiD· 1 shared Jaskaran Khinda· 1 shared Jesse Fox· 1 shared

Activity by Year

2021-2025 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Anusha KameshORCID

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2 papers

Recent·Most cited

Neurosciencenpj Parkinson s DiseasePeer-reviewedMay 3, 2025

Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition

Anusha Kamesh, Chelsie Kadgien, Naila Kuhlmann…·Austen J. Milnerwood

This study shows that VPS35(D620N) mutation leads to increased glutamate and dopamine transmission in mice, which can be reversed by LRRK2 inhibition.

1 citation

mouseelectronic health records

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NeuroscienceMolecular BrainPeer-reviewedSep 16, 2021

Surface GluA1 and glutamate transmission are increased in VPS35 D620N neurons and altered by LRRK2 kinase inhibition

Chelsie Kadgien, Anusha Kamesh, Jaskaran Khinda…·Austen J. Milnerwood

This study investigates the effects of the VPS35 D620N mutation on neuronal function, finding increased GluA1 surface expression and altered glutamate transmission, with LRRK2 inhibition affecting GluA1 levels.

19 citations

mouseexperimental assay

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