Anusha Kamesh

The paper investigates how LRRK2 activity affects dopamine release in mice, showing age- and sex-dependent changes and rapid reversal with inhibition in certain groups.

The paper examines age and sex-dependent changes in dopamine release in dorsal and ventral striatum of mice, finding increased dorsal striatal release in males during adolescence to young adulthood, linked to behavioral changes.

This study shows that VPS35(D620N) mutation leads to increased glutamate and dopamine transmission in mice, which can be reversed by LRRK2 inhibition.

The paper identifies molecular signatures of neuronal hyperexcitability and lithium responsiveness in bipolar disorder neurons, suggesting new therapeutic strategies targeting Akt and AMPK pathways.

This study investigates the effects of the VPS35 D620N mutation on neuronal function, finding increased GluA1 surface expression and altered glutamate transmission, with LRRK2 inhibition affecting GluA1 levels.

This study shows chronic lithium treatment reduces neuronal excitability and shifts the excitatory/inhibitory balance toward inhibition in mouse cortical neurons.