Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase
Eric Z. Pang, Boyu Zhao, Cameron Flowers, Elizabeth Oroudjeva, Jasmine B. Winter, Vijaya Pandey, Michael R. Sawaya, James Akira Wohlschlegel, Joseph A. Loo, José A. Rodríguez, Steven Gerard Clarke
This paper shows PCMTD1, a cullin-RING ligase, recognizes L-isoaspartyl residues and targets damaged proteins for ubiquitylation and degradation.
Journal of Biological Chemistry · Sep 19, 2025Peer-reviewedBiochemistry