James Akira Wohlschlegel

This study identifies RRsS1 as a dual-binding scaffold that stabilizes Pol IV transcription complexes to enhance siRNA biogenesis in plant reproduction.

The paper identifies J-domain proteins as mediators of PKL recruitment to gene promoters, enabling H3.3 deposition and influencing gene expression through interactions with transcription factors and ATRX.

This paper identifies that truncating variants in KAT6A cause two distinct neurodevelopmental disorders with opposing gene regulatory and metabolic effects, highlighting the need for variant-level stratification in therapy development.

The paper identifies a conserved vesicular circuit that maintains heme homeostasis by rerouting intracellular heme flux, showing its role in metabolic adaptation across species.

This study identifies FBXO42's role in regulating PPP4C and p53 signaling, showing its importance in cancer cell survival through genetic and proteomic analyses.

This study shows that Acyl Carrier Protein (ACP) is essential for apicoplast biogenesis in blood-stage P. falciparum malaria parasites, independent of its role in fatty acid synthesis.

The paper identifies a putative metal transporter in the apicoplast of malaria parasites, showing it is essential for gametocyte development but not asexual stages.

This study identifies an intracellular role for Semaphorin-2a in Drosophila oogenesis by inhibiting Cappuccino-mediated actin polymerization and affecting oskar mRNA localization.

The paper investigates PABPC1's role in alternative polyadenylation during B cell development, finding it primarily shortens and downregulates its targets in a context-dependent manner.

The paper identifies IFI16 as a host protein interacting with SARS-CoV-2 NSP8/NSP10, showing that IFI16 promotes coronavirus infection independently of its role in type I IFN regulation.

The paper identifies TXNDC15 as a regulator of ER membrane protein quality control, showing its dual role in modulating MARCHF6 activity and its link to ciliogenesis defects in Meckel-Gruber syndrome.

The paper identifies the GYS1 interactome in brown adipocytes using proximity labeling, revealing novel interactors and broader functional roles beyond glycogen synthesis.

This study identifies YAF9A and YAF9B as chromatin readers essential for DNA double-strand break repair in Arabidopsis via homologous recombination pathways.

This paper shows PCMTD1, a cullin-RING ligase, recognizes L-isoaspartyl residues and targets damaged proteins for ubiquitylation and degradation.

This study identifies IMT1 as a protein linking the inner membrane complex and subpellicular microtubules in Toxoplasma gondii, revealing its role in regulating cytoskeletal interactions.

This paper identifies the interactome of yeast peroxiredoxin Tsa1, revealing its role in redox regulation of metabolism, glycolysis, and zinc homeostasis through interactions with Pyk1, Fba1, and Zap1.

The paper identifies CRTC1-proximal proteins in neurons and reveals cooperative chromatin binding between CREB1 and CRTC1 with MEF2C and RFX3 during synaptic activity.

The paper identifies Arabidopsis REM transcription factors and GDE1 as key regulators of DNA methylation by recruiting RNA Polymerase IV to generate 24nt-siRNAs that direct methylation to specific genomic loci.

The paper identifies human kinase motifs in viral proteomes, showing enrichment for stress and immune-related kinases and their phosphorylation in infected cells.

This study identifies Mdm38/LETM1 as a protein that links ion homeostasis and proteostasis in the mitochondrial inner membrane in yeast.

This study identifies BDH proteins as conserved subunits of plant SWI/SNF complexes, showing their role in complex stability and hypocotyl elongation through interactions with ARP4-ARP7.

This study identifies PfHO as essential for apicoplast biogenesis and gene expression in Plasmodium falciparum, revealing its role in maintaining apicoplast-encoded RNA levels.

The paper identifies a conserved CYC-YPMF motif in Pol IV critical for CLSY docking, essential for small RNA biogenesis and transposon silencing.

This study identifies EDC-3 and EDC-4 as regulators of mRNA decay and biomolecular condensate specialization during C. elegans embryonic development.

This study identifies how paramyxovirus matrix proteins inhibit host cell translation by interacting with the exon-junction complex, enhancing viral replication.

The paper analyzes the secreted proteome of oligodendrocytes and progenitor cells to reveal their roles in extracellular matrix formation and inflammation regulation.

The paper identifies RBM5 and RBM10 as U2 snRNP subunits that interact with intron branch sites and regulate splicing by acting as silencers.

This paper identifies SCFFBXL5 as a regulator of VHL stability and HIF1α-dependent hypoxia response.

The paper maps neurotransmitter receptor subtypes and protein complexes to synapses in Drosophila using molecular and connectomic techniques.