Vijaya Pandey

A B1 SINE element within the mouse Malat1 long noncoding RNA acts as an internal ribosome entry site mediating micropeptide translation

Dominant truncating variants in KAT6A cause two neurodevelopmental disorders with opposite gene regulatory and metabolic changes

This paper identifies that truncating variants in KAT6A cause two distinct neurodevelopmental disorders with opposing gene regulatory and metabolic effects, highlighting the need for variant-level stratification in therapy development.

A conserved vesicular circuit enables metabolic adaptation and maintains systemic heme homeostasis

The paper identifies a conserved vesicular circuit that maintains heme homeostasis by rerouting intracellular heme flux, showing its role in metabolic adaptation across species.

The regulation of Protein Phosphatase 4 by FBXO42 is required for cancer cell survival.

This study identifies FBXO42's role in regulating PPP4C and p53 signaling, showing its importance in cancer cell survival through genetic and proteomic analyses.

Mapping the Glycogen Synthase 1 Interactome in Brown Adipocytes

The paper identifies the GYS1 interactome in brown adipocytes using proximity labeling, revealing novel interactors and broader functional roles beyond glycogen synthesis.

Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase

This paper shows PCMTD1, a cullin-RING ligase, recognizes L-isoaspartyl residues and targets damaged proteins for ubiquitylation and degradation.

Plant BCL-Domain Homologues play a conserved role in SWI/SNF complex stability

This study identifies BDH proteins as conserved subunits of plant SWI/SNF complexes, showing their role in complex stability and hypocotyl elongation through interactions with ARP4-ARP7.

CLSY docking to Pol IV requires a conserved domain critical for small RNA biogenesis and transposon silencing.

The paper identifies a conserved CYC-YPMF motif in Pol IV critical for CLSY docking, essential for small RNA biogenesis and transposon silencing.

Secretome analysis of oligodendrocytes and precursors reveals their roles as contributors to the extracellular matrix and potential regulators of inflammation

The paper analyzes the secreted proteome of oligodendrocytes and progenitor cells to reveal their roles in extracellular matrix formation and inflammation regulation.

SCF FBXL5 ubiquitin ligase regulates stability of von-Hippel Lindau protein and the HIF1α-dependent response to hypoxia

This paper identifies SCFFBXL5 as a regulator of VHL stability and HIF1α-dependent hypoxia response.

Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome

The paper maps neurotransmitter receptor subtypes and protein complexes to synapses in Drosophila using molecular and connectomic techniques.

Extracellular matrix and microglial regulation of cognitive aging

The paper investigates how microglia and the extracellular matrix influence cognitive aging by analyzing ECM composition, microglial interactions, and their relationship with synapses and behavior.