Direct expression of CPT1a enables a high throughput platform for the discovery of CPT1a modulators
Jason Chen, Tuyen Tran, Anthony Wong, Luofei Wang, Pranavi Annaluru, Vibha Sreekanth, Samika Murthy, Laasya Munjeti, Tanya Park, Utkarsh Bhat, Glynnis Leong, Y Li, Simeng Chen, Natalie Kong, Rushika Raval, , Zhan Chen
The paper develops a high-throughput platform using catalytically active CPT1a to screen for modulators, validated with known inhibitors and a library of small molecules.
Applied Biosciences · May 12, 2025Peer-reviewedBiochemistry