Farnesoid X receptor-dependent microbiome-bile acid signaling mediates obstructive sleep apnea-induced atherosclerosis
Jin Xue, Celeste Allaband, Simone Zuffa, Dan Zhou, Orit Poulsen, Jason D. Meadows, Daniel T. McDonald, Madison Ambre, Gail L. Ackermann, Amanda Birmingham, Jennifer H. Cao, Ipsita Mohanty, Pieter C. Dorrestein, Rob D. Knight, GG Haddad
This study shows that FXR deficiency prevents IHC-induced atherosclerosis by disrupting microbiome-bile acid signaling in ApoE-/- mice.
bioRxiv · Apr 1, 2026 · PreprintMicrobiology